SA makes strides in medical research

first_imgThe Technology Innovation Agency has joined the patent pool with the goal of boosting its research into tuberculosis drugs. (Image: USAid)   South Africa’s Technology Innovation Agency has become the world’s first governmental body to join the Pool for Open Innovation against Neglected Tropical Diseases, established in 2009 by pharmaceutical giant GlaxoSmithKline (GSK).Originally known as the GSK and Alnylam Intellectual Property Pool, the initiative facilitates access to intellectual property, knowledge, technologies, and products for companies – wherever they are in the world – that work on combating tropical diseases.Soon after the pool’s launch, it underwent a name change to encourage other pharmaceutical companies, which might be deterred by the close tie to GSK, to join and contribute.Now the Technology Innovation Agency (TIA), which was set up to boost scientific innovation in South Africa and is managed according to the TIA Act of 2008, has decided to become a member of the pool.This move is expected to boost the agency’s own plans to stimulate tropical disease research in South Africa.Local researchers will instantly gain access to over 2 300 current drug patents, and will also benefit from the shared knowledge of their international colleagues in significant diseases such as malaria and tuberculosis.As a pioneering member, the TIA’s move was recently matched by the Massachusetts Institute of Technology, which became the first university to join the pool.TIA health portfolio manager Dr Carl Montague said that his company is available to help other South African companies implement plans based on information they get from the pool.“We have to ensure that the pool can be meaningfully exploited,” he said.According to the World Health Organisation (WHO), South Africa has one of the highest tuberculosis burdens in the world. The disease is also an opportunistic killer that often targets people living with HIV/Aids, and has been confirmed as the leading cause of death among these patients.Working togetherThe patent pool is administered independently by biotechnology development NGO Bio Ventures for Global Health, based in Washington DC.Based on the Food and Drug Administration’s identification of the neglected tropical diseases it is targeting in its own initiative, 16 diseases have come under the spotlight. They are tuberculosis; malaria; blinding trachoma; buruli ulcer; cholera; dengue and dengue haemorrhagic fever; dracunculiasis (guinea worm disease); fascioliasis; human African trypanosomiasis (sleeping sickness); leishmaniasis; leprosy; lymphatic filariasis; onchocerciasis; schistosomiasis (bilharzia); soil transmitted helminthiasis; and yaws.It is hoped that, with greater access to intellectual property, the patent pool will lead to new developments in the control of these diseases. GSK has also said it will release some of its drug patents and manufacturing processes, making them available to others without asking for royalties.Membership of the pool, which is voluntary, has been slow to gather momentum, but with the TIA and the world-renowned Massachusetts research university endorsing the initiative by joining, hopes are high that more companies will take the same step.GSK announced earlier in 2010 that it would partner with iThemba Pharmaceuticals, a new Gauteng-based company funded by the Department of Science and Technology, to conduct research into a tuberculosis drug, using technology garnered from the pool and that was submitted by Alnylam Pharmaceuticals.This US-based company was the first to release its patents into the pool, adding around 1 500 in 2009. The Alnylam patents focus on RNA interference techniques, which allows the selective shutting off and tuning on of genes in living cells.The two researchers who developed the technique shared the Nobel Prize for Physiology or Medicine in 2006, and the drugs based on this technique of gene silencing are known as RNAi therapeutics.More such initiatives are expected to flourish as the patent pool’s member base grows in size.Targeting diseaseThe improved control of neglected tropical diseases is a priority of the WHO, which in 2007 called for more funding for research and development into treatment and management strategies.These bacterial and parasitic diseases affect over 1.4-billion people around the world, mostly in Africa, Southeast Asia and Latin America.They are both a cause and a symptom of poverty, proliferating in conditions of poor sanitation, inadequate housing and ineffective insect control. They trap people in a cycle of unemployment and social isolation, leaving them unable to care for their families or themselves.The word “neglected” is used to describe them because major diseases such as malaria, tuberculosis and Aids tend to get more funding and support from policy makers and organisations, while lower-profile diseases, although their eradication also presents an opportunity to lift people out of poverty, fall by the wayside.According to the Global Network for Neglected Tropical Diseases, the worldwide burden of these illnesses is equal to at least half the total burden of HIV/Aids, tuberculosis and malaria combined.last_img read more


Oracle And Salesforce Bury The Hatchet—Surprisingly, Not In The Others’ Back

first_imgCognitive Automation is the Immediate Future of… brian proffitt Related Posts Say this for Larry Ellison. He can sometimes shoot off his mouth and piss people off, but when things get tough, he’ll do whatever it takes to push Oracle forward and set things right for his company.That may be biggest takeaway from Oracle’s just-announced alliance with hated rival Salesforce.com, a nine-year partnership that will put Salesforce.com’s cloud-based customer-management software atop Oracle apps and infrastructure. That includes using Exadata systems, Oracle’s database, Oracle’s Java middleware and Oracle Enterprise Linux.This partnership may be the clearest sign yet that Oracle is under intense pressure from customers who are more interested in “alternative” but fast-growing database-related technologies such as non-relational NoSQL databases and commodity storage like Hadoop.The success of those technologies is probably the number one reason that this deal happened in the first place. The world is not a friendly place for companies like Oracle anymore, and it needs friends wherever it can find them. Even if that means turning to companies it’s long poked with sharp sticks, like Salesforce and Microsoft (with whom it struck a related sort of partnership earlier this week).(See also Oracle Makes More Big Promises After Missed 4Q Earnings and Microsoft/Oracle: A Yawner That Could Have Been Much More)Ellison had been promising a big announcement that would blow away the tech community. Many observers, including me, regarded this as so much Ellison jive, especially after the “big” Oracle-Microsoft partnership turned out to be little more than Oracle databases running on the Windows Azure cloud service. In this case, we were way off the mark.I Now Pronounce You Marc & LarryThat’s Larry on the leftToday’s announcement is the real deal: two huge cloud and data service providers who have been sniping at each other professionally for years setting those differences aside and getting a deal done.But to actually see it happen, to hear Salesforce.com CEO Marc Benioff actually say nice things about Oracle’s services after so many public potshots was just, well, weird.For Oracle, this is a good deal all around. It needed a big boost to showcase its database and cloud offerings, which were increasingly being eclipsed by the white-hot spotlight shining on Hadoop, NoSQL and other big data technologies.The fact that Oracle will be using Saleforce.com as its customer relation management (CRM) platform could be the biggest benefit for Salesforce.com. That in itself is a pretty big deal, especially after Oracle bought Siebel, then the world’s biggest CRM company, back in 2005.One thing is for sure—Ellison must have cut Benioff one hell of a deal. 3 Areas of Your Business that Need Tech Nowcenter_img IT + Project Management: A Love Affair Massive Non-Desk Workforce is an Opportunity fo… Tags:#cloud computing#Oracle#Salesforce.com last_img read more


New hope for thalassemic Sukhsohit as PM forwards Ambika Soni’s recommendation

first_imgSukhsohit, who suffers from thalassaemia, has been rejected by the UPSC on medical grounds.Prime Minister Manmohan Singh on Tuesday forwarded Information and Broadcasting Minister Ambika Soni’s letter on thalassemic civil services aspirant Sukhsohit Singh to the Minister for Personnel Affairs in Prime Minister’s Office (PMO), V. Narayanswami, for further action. The latest development gives a new lease of life to Sukhsohit’s dream of becoming an Indian Administrative Service (IAS) officer following a Headlines Today campaign started about a last ago. Sukhsohit has been rejected twice on medical grounds for being thalassemic, firstly by Safdarjung Hospital and most recently by Ram Manohar Lohia Hospital. He had become the first thalassemia major patient to clear the civil services examination in 2008 securing a rank of 833 in the general category despite his medical condition which require blood transfusion every 15 days. Soni had on Monday written to the prime minister urging him to take up the matter. Minister of State for Health Dinesh Trivedi also met Sukhsohit on Tuesday and assured him that he would take up his case. Sukhsohit was also positive after his meeting with Trivedi. Earlier, Narayanswami had last week said that he would be the first person to accommodate the youth if he clears it.For more news on India, click here.For more news on Business, click here.For more news on Movies, click here.For more news on Sports, click here.last_img read more


Singapore reports 1st case of rare monkeypox virus

first_imgSingapore: Singapore has reported its first ever case of monkeypox, brought in by a Nigerian man thought to have contracted the rare virus by eating bushmeat at a wedding. Symptoms in humans of monkeypox — which is endemic in parts of Central and Western Africa — include lesions, fever, muscle ache and chills. Transmission is usually via close contact with infected animals such as rodents and monkeys and is limited between people. It is not normally fatal but has been in rare cases. Also Read – Saudi Crown Prince Salman ‘snubbed’ Pak PM Imran, recalled his private jet from US: ReportThe man who brought in the virus arrived in Singapore on April 28, the city-state’s health ministry (MOH) said in a statement late Thursday. The 38-year-old developed symptoms two days later and is currently isolated at an infectious disease centre in a stable condition, the ministry said. Another 23 individuals who had been in close contact with the man have also been quarantined and will be monitored for 21 days. “While risk of spread is low, MOH is taking precautions,” the ministry said. Also Read – Iraq military admits ‘excessive force’ used in deadly protestsOutside Africa, human moneypox infections had only been previously reported in the United States, Britain and Israel, according to the US Centers For Disease Control and Prevention. Singapore, a tiny but affluent city-state dependent on external trade and tourism, has toughened measures against infectious diseases after it was hit hard by the 2003 SARS virus outbreak. The disease killed 33 people in Singapore, inflicted major losses on the economy and hit the number of international visitors.last_img read more


Metro services affected on Yellow Line due to technical snag

first_imgNew Delhi: Services were disrupted on the Yellow Line of the Delhi Metro on Tuesday morning due to a technical glitch, leaving many passengers stranded. Yellow Line connects Samaypur Badli in the city to Huda City Centre in Gurgaon. Due to the snag, commuters had a hard time reaching their destination and many passengers were stranded at the Qutub Minar station. “Due to a technical snag at Chattarpur, train services have been affected on the Yellow Line. The issue is being rectified,” a senior DMRC official said. Trains are being run in following loops temporarily — between Huda City Centre and Sultanpur and between Samaypur Badli and Qutub Minar, he said. “There will be no train movement between Sultanpur and Qutub Minar,” he said.last_img read more


Exequiel Palacios to be Real Madrids first January signing

first_imgReal Madrid reportedly will shortly announce the signing of young River Plate star Exequiel PalaciosThe 20-year-old midfielder will become Real’s first signing of the January transfer window, despite there being another six weeks before it opens.Palacios is regarded as one of the brightest young prospects in South America and had reportedly captured the interest of several European giants.Barcelona, Paris Saint-Germain and Inter Milan were all believed to have expressed an interest.In August, Palacios revealed in an interview that he had turned down Serie A side Torino last year.But River Plate president Rodolfo D’Onofrio revealed that he had met with Real officials in regards to a deal for Palacios last week.David Villa, FC BarcelonaTop 10 players who played for both Barcelona and Valencia Boro Tanchev – September 14, 2019 Time to talk about the best players who represented both Barcelona and Valencia, prior to their La Liga encounter at Camp Nou this evening.Now Marca reports Real director Emilio Butragueno has pulled off the deal after a minor delay due to River Plate’s reluctance to sell.The transfer is set to be announced after the Copa Libertadores final between River Plate and Boca Juniors.Los Blancos will reportedly compensate River Plate with over €20m for Palacios, who will sign a contract until June 2024 upon his arrival at Madrid in January.Since debuting in 2015, the Argentine has provided four goals and five assists in 38 games for River Plate.Palacios even made his first two appearances for the Argentina senior team in September.last_img read more


FA to investigate Raheem Sterling racial abuse

first_imgThe Football Association has announced that it’s conducting an investigation into the alleged racial abuse suffered by Raheem Sterling at Stamford Bridge on Saturday.Television cameras picked up a couple of Chelsea supporters shouting alleged racial slurs at Sterling, as he went to pick up the ball for a City corner kick.Both Chelsea and the London Metropolitan Police have released statements saying they will be investigating the incident.Sterling released a statement on Instagram condemning the abuse on Sunday.Premier LeaguePremier League Betting: Match-day 5 Stuart Heath – September 14, 2019 Going into the Premier League’s match-day five with a gap already beginning to form at the top of the league. We will take a…According to Sky Sports, the English Football Association has now released a statement that read: “We take all allegations of discrimination extremely seriously and will work with the clubs and the relevant authorities to ensure this matter is dealt with appropriately.“We strongly condemn all forms of discrimination and encourage all fans and participants who believe that they have been the subject of, or witness to, discriminatory abuse to report it through the appropriate channels: The FA, our County FAs or our partners Kick It Out.”last_img read more


Wheels of Change offers parttime jobs transportation for homeless

first_img“Wheels of Change” offers part-time jobs, transportation for homeless 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave Settings Updated: 3:25 PM Posted: February 26, 2018 , center_img Categories: Good Morning San Diego, Local San Diego News FacebookTwitter 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsThe City of San Diego has announced a new program that provides day jobs and transportation for homeless people. Councilmember Scott Sherman says the program, called “Wheels of Change,” could help address one aspect of a multifaceted issue.“There’s a segment of the homeless who do want to work and want to try and get back on their feet,” Sherman said. “They’re out there.”A van will pick up 10 to 12 people at a time and take them to do jobs like weed-pulling, brush abatement and litter cleanup. Sherman says this will make city employees available for other jobs while helping people get on their feet. It may also help homeless people build networks with people who can help them find permanent housing.The first six months of the program will be funded by the private citizen who first brought the idea to the city.“They believed in it so strongly that they’re going to fund the first six months,” Sherman said. “They already bought the van. It’s all ready to go. It just shows that this is a community wide program and it takes more than just one segment of the community trying to solve it.”KUSI’s Ed Lenderman was live at the Barrio Logan bridge shelter on Good Morning San Diego with more information. February 26, 2018last_img read more


Proposed Circus Cruelty Prevention Act impact on animal refuges

first_img February 28, 2019 KUSI Newsroom, Posted: February 28, 2019 Proposed Circus Cruelty Prevention Act impact on animal refuges KUSI Newsroom 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – State Senator Ben Hueso recently introduced a bill aimed at prohibition on use in traveling animal acts but according to the organization Wild Wonders the bill would basically be the death of wild animal refuges in California.Senate Bill -313 also known as the Circus Cruelty Prevention Act proposes would prohibit a person from using, or allowing to be used, a wild or exotic animal, as defined, in a traveling animal act.The part that Wild Wonders Execuative Director Jackie Navarro says will impact the program is the bill would prohibit outreach educational programs unless they are provided by an organization which is accredited by the Association of Zoos and Aquariums or the Global Federation of Animal Sanctuaries.“Wild Wonders and hundreds of other smaller private zoos will go out of business, and the incredible learning opportunities provided to children will cease to exist,” said Navarro. Categories: Good Morning San Diego, Local San Diego News, Politics FacebookTwitterlast_img read more