Biologist receives research grant

first_imgNotre Dame biology professor Zachary T. Schafer received a Research Scholar Grant from the American Cancer Society (ACS) to further his research on breast cancer treatment.The grant is funded by Lee National Denim Day, a program sponsored by Lee Jeans, in which people donate $5 for an opportunity to wear jeans to work. According to the website, the program has raised more than $91 million dollars for the fight against breast cancer, and $792,000 of that total will go toward furthering Professor Schafer’s research project, “The Evasion of Detachment-Induced Metabolic Defects in Breast Cancer.”“[It is] great to be part of the Department of Biological Sciences here where there is a significant track record of obtaining substantial extramural funding in spite of the difficult funding climate,” he said. “I’m very grateful for the support from the ACS and for the funds from National Denim Day.”Schafer said his research primarily deals with exploring the metastatic cascade, or the molecular mechanisms that cancer cells use to survive while traveling from the site of the primary tumor to distant sites in the body.“We have data demonstrating that pathways involved in cellular metabolism are critical for the survival of cancer cells during metastasis,” Schafer said. “[We] hope that better understanding how cancer cell metabolism is regulated will open up new targets for the development of drugs that target metastasizing cancer cells for elimination.”Schafer said gaining this understanding could greatly enhance how breast cancer patients are treated and potentially reduce mortality rates.“This type of chemotherapeutic strategy could be particularly helpful in that it could inhibit metastasis. Most patients that die from cancer die due to metastasis,” he said. “In excess of 90 percent of cancer mortalities are due to metastasis.”His research also explores how cancer cells shut down anoikis, a programmed cell death that inhibits cancer cell growth, and ways in which cancer cells use nutrient consumption to survive in an abnormal environment.“As we accumulate more information about breast cancer biology and technology improves over time, we will move towards individualized cancer treatment,” he said. “Using this information, physicians may be able to personalize therapies to target each person’s cancer most effectively.”The funds will help Schafer maintain the supplies, staff and scope his research requires.“The grant  will go mostly towards salaries for laboratory personnel and supplies for our experiments,” he said. “It also supports travel to conferences to disseminate the results of our research.”Schafer also believes that the fight against breast cancer and other diseases is a team effort.“Get involved in research,” he said. “There are a number of possible research-related careers that students can pursue, and all can contribute in unique ways to helping fight diseases like breast cancer.”Tags: American Cancer Society, cancer, Lee National Denim Day, Research Scholar Grant, Zachary T. Schaferlast_img read more


Toni Braxton & Babyface Visit After Midnight Before Taking the Stage

first_img After Midnight Related Shows Toni Braxton and Kenneth “Babyface” Edmonds had a late-night date with the cast of After Midnight on February 6! The pair, who have racked up a total of 16 Grammy Awards between them, will take the stage as celebrity guest soloists in the toe-tapping tribute to Duke Ellington this spring. Before it’s their turn to croon with the Jazz at Lincoln Center All Stars Orchestra, Braxton and Babyface took in the extravaganza at the Brooks Atkinson Theatre, and after the show, the stars stopped backstage to snap a photo with their new castmates. Check out this Hot Shot of the stars, then catch their Broadway guest appearance in After Midnight from March 18 through 30! View Comments Show Closed This production ended its run on June 29, 2014last_img read more


Biotech Association warns legislation would make VT least friendly state for biotech and life sciences

first_imgIn testimony to the Legislature, New England Biotech Association (NEBA) has warned that a bill under consideration by the Vermont Legislature will create the most restrictive and onerous regulatory environment for biotechnology growth and development in both New England and the nation. The bill, 48/H. 270, would established stricter controls on interactions between the biopharmeceutical industry and health care professionals.      The legislation would eliminate existing protections of trade secrets, create an unneeded new state bureaucracy, and drive away research funding by mandating additional disclosure of expenditures, said NEBA spokeswoman Paula Newton, adding that four other states have rejected similar legislation.”Plain and simple, this legislation will harm Vermont’s biotechnology and life sciences sector and drive jobs away,” Newton said.NEBA serves as the regional policy and public affairs voice for the biotechnology and biopharmaceutical community, representing state biotech associations, companies, academic institutions, and other organizations consisting of more than 800 entities.”Vermont already has one of the strictest pharmaceutical marketing disclosure laws in the country, so the onerous regulatory regime contemplated by the Legislation is wholly unnecessary and should bedefeated,” continued Newton. “Physicians are trusted professionals, and introducing unreasonably broad controls and prohibitions on the interactions between the biopharmaceutical industry and doctors is unwarranted and contrary to health interests of Vermonters who stand to benefit from miracle drugs.”Four other states, including New England states Maine and Rhode Island, have recently rejected marketing restriction legislation far less extreme than the Vermont bill, declaring the measures as bad policy with negative consequences for the life sciences industry and the jobs it produces. An overly restrictive disclosure law recently passed in Massachusetts — less strict than the Vermont proposal — has resulted in a drop in clinical trials and the cancellation of a major medical convention and the associated tourism and tax revenue.NEBA is a non-profit, member-driven organization comprised of state biotech associations, companies, academic institutions, and other organizations with a collective mission to support and grow the biotechnology industry in New England.MONTPELIER, Vt., April 24 /PRNewswire/ –olast_img read more


Anstead: Court funding moving in the right direction

first_img Anstead: Court funding moving in the right direction Senior EditorA potentially troublesome concept for revamping the courts that was floated in the Florida House has been dramatically changed for the better, but lawyers still need to be vigilant in the closing days of the legislature, according to Supreme Court Chief Justice Harry Lee Anstead.Anstead addressed the Bar Board of Governors earlier this month about legislative efforts to deal with Revision 7 to the Florida Constitution. That 1998 voter-approved amendment mandates that the state assume from counties a larger share of operational funding for trial courts by July 1, 2004.His impassioned speech sparked a standing ovation from the board, which also approved a recommendation from the Communications Committee to set up a special committee to educate the public about Article V issues.“The [House] legislative committee yesterday released [its proposed] legislation that, I can tell you, I’m very appreciative of. It has moved in the right direction toward the position that was taken by the Senate,” Anstead told the board. “There is some movement, and that movement would have not occurred without the help of all of you and the lawyers you represent back in the home communities.. . . “I’m pleased. And I’m optimistic. Well, I can’t afford to be optimistic,” he added, noting there could be more changes as House and Senate representatives work out differences in a conference committee.“Keep your eye on the ball for the entire ball game. We cannot afford to not leave everything out there on the playing field if we are going to preserve Florida’s court system in the next two years,” he said. “We are now moving in the right direction this year, but this is crunch time.”Anstead recounted that he had visited 15 newspaper editorial boards, and most followed up with editorials supporting the court system. And he said Senate leaders worked closely with the courts to carry out their interpretation of Revision 7.He also recounted the history of the funding issue. It began in 1972, he said, when the unified state court system was approved by voters, doing away with municipal and local courts. The agreement was the state would fund the entire court system, but that never happened. Counties found themselves paying a high proportion of court costs, a bill that became more costly as county revenues became increasingly strained.In 1997, the Constitution Revision Commission approved as part of its recommendations an amendment mandating the state take over more of the court system funding, and specifying how that would be done. Former Chief Justice Alan Sundberg played a major role in drafting the amendment, Anstead said, and also an explanatory statement from the CRC that the amendment was intended to be a straight, simple funding transfer. The CRC also built in a six-year window, so the switch could be accomplished in steps.But because of budget concerns in past years, little was done, leaving a compressed two-year time frame to figure out exactly what costs the state would pick up and where the money was coming from. Initial ideas during the 2003 session, he said, would have left Sundberg spinning in his grave.Even members of the House committee said they didn’t know where some of the lower chamber’s initial ideas came from or who was backing them, Anstead said. But representatives also noted those were only ideas and general concepts, and were never drafted into an actual bill.Thanks to continued efforts from judges, the Bar, lawyers, and others, the bill finally presented to the House Select Committee on Article V was much improved from some of the initial concepts.And the courts were able to determine that the actual cost to the state for the judicial part of Revision 7 would be $190 million, unlike some estimates that ranged up to $500 million or more.While the Revision 7 issues have been and will continue to be challenging, board members are lucky they have a chance to make such a positive contribution, Anstead said.“How many people are actually privileged to be there at a time of crisis in our society and can get in on it and preserve or make better a value in our country?” he asked. “And that value is our form of government, and that is what is being threatened.”He quoted Shakespeare from Henry II and a comment on the Battle of Hastings, which shaped English history: “Old men will weep that they weren’t there that day.”Board member David Welch, chair of the Communications Committee, said that the committee approved a recommendation from board member Ervin Gonzalez to create a task force to educate the public about the importance of providing adequate funding for the courts.“We’ve got to take charge and go forward and make whatever efforts are needed to coordinate the message with the Supreme Court,” Gonzalez said. “If we don’t do this, if we don’t have a good plan, we should plan to fail and lose the judiciary as we know it. No one is as well suited to take on this issue as The Florida Bar.”Added Welch: “It will be a Florida Bar task force to ensure proper implementation of Revision 7.”He and others said details about what the task force will do still have to be worked out. Board member Chobee Ebbets, a member of the Communications Committee, said there should be a member from each circuit, and the panel should focus on getting word out at the circuit level and to local lawyers.“The desire of many members on the Communications Committee is exactly what Mr. Ebbets said, to provide greater resources to our circuits around the state,” said board member Jennifer Coberly. “We very, very strongly agree with what the chief justice said today. It is time for the Bar to step up today.”The board approved the recommendation unanimously. April 30, 2003 Gary Blankenship Senior Editor Regular News Anstead: Court funding moving in the right directionlast_img read more


Copiague Man Sentenced for $30M Mortgage Scam

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York A Copiague man was sentenced Friday to 12 ½ years in federal prison for conning banks out of more than $30 million in a mortgage scam over a six-year span.Aaron Wider had been convicted of conspiracy to commit bank fraud last year following a month-long trial at Central Islip federal court.“Wider’s scheme won him millions of dollars in profits and delivered a crushing blow to the financial institutions who became unwitting players in this game,” said William Sweeney, Jr., assistant director of the FBI’s New York field office. “But as we know, banks aren’t the only victims in these types of fraud-for-profits scams. A compromised banking system, which threatens both the stability of our economy and the safety of our assets, is a risk to us all.”Authorities said the 50-year-old man, the owner and CEO of the Garden City-based mortgage bank HTFC Corp. from 2003 to ‘08, and his co-defendants engineered a series of sham transactions to artificially inflate the prices of homes in order to secure funding from other banks and financial institutions known as “warehouse lenders.”Those lenders in turn relied on HTFC to ensure that the home buyers were financially able to pay the mortgages and that the homes were properly appraised, prosecutors said. But the fraudulent loan applications and appraisals to the warehouse lenders nearly doubled the true sales prices of the homes, according to investigators.Wider and others also inflated their own personal assets, used straw purchasers and sham trust entities and concealed significant liabilities to get loan approval, authorities said. HTFC sold each of its mortgages in the secondary market, but it wasn’t until HTFC’s mortgages went into foreclosure beginning in ’07 and ’08 did investors discover that the actual value of the collateral was far less than the amount borrowed for each home, prosecutors said.In addition to prison time, Judge Arthur Spatt also ordered Wider to serve five years of supervised release and pay $22,487,799 in forfeiture and restitution.last_img read more


Senators recognize CUs’ importance, tout reg relief efforts

first_img continue reading » 18SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr The Senate is working toward bipartisan regulatory relief for credit unions, a few senators told hundreds of industry representatives at NAFCU’s Congressional Caucus on Tuesday.Credit union representatives heard directly from Senate Appropriations Subcommittee Chairman Shelley Moore Capito, R-W.Va., and Senate Banking Committee members Heidi Heitkamp, D-N.D., and Mike Rounds, R-S.D.Speaking on issues ranging from the regulatory burden caused by the Dodd-Frank Act to the need to hold retailers accountable for data security breaches that occur on their end, senators reaffirmed for Caucus attendees the importance of credit unions in the financial services industry.last_img read more


Vestal Museum opens with ‘Conversation on Conservation’

first_imgVESTAL (WBNG) — The Vestal Museum held a ‘Conversation on Conservation’ Saturday, marking the museum’s reopening after being closed due to the COVID-19 pandemic. The event also featured an exhibit by Vestal photographer George Allen featuring some of those birds, plants and insects. “George Allen has planned a lot of fun activities for the kids with stickers and handouts and all different kinds of stuff,” said Art Gallery Director Jessica Petrylack. “We always welcome kids here at the museum.” Organizers say this is the first of many events the museum plans to hold outside this summer depending on the weather. Local conservation agencies set up individual exhibits outside the museum to raise awareness about the dangers of pesticide use, and took time to teach visitors about local bird and plant species. last_img read more


Beachside design by former contestant from The Block sells for $2.075 million at auction

first_imgMore from news02:37Purchasers snap up every residence in the $40 million Siarn Palm Beach North8 hours ago02:37International architect Desmond Brooks selling luxury beach villa1 day ago18 Nagel Ave MiamiAs the couple’s third beachside build, they were looking for a “bulletproof” home to accommodate their three children.“We got Carlene on board and she helped us make some really strong decisions with colours and features,” Mr Brookes said.“Designing beach houses has become a big hobby for Renee and I but now that we have kids we are using materials that are a bit more hardy.” 18 Nagel Ave, Miami.A HOME styled by reality TV star from The Block, Carlene Duffy, has sold for $2.075 million.The Miami home sold under the hammer last Sunday to a Gold Coast couple. Sellers Nathan and Renee Brookes created the ultimate beachside sanctuary with the help of architect John Campbell and their friend, The Block 2014 contestant, Carlene Duffy. 18 Nagel Avenue MiamiThe home has polished concrete floors and an open floor plan which flows into a children’s retreat.The home was previously on the market for offers over $2 million.Ron London of London Estate Agents Mermaid Beach negotiated the sale.last_img read more


The Ascension

first_img Share 35 Views   no discussions Tweet Sharing is caring! Sharecenter_img FaithLifestyleLocalNews The Ascension by: – June 4, 2011 Share Photo credit: rationesola.blogspot.comThe paschal mystery refers not simply to the death and resurrection of Jesus, but also to his ascension and the sending of the Spirit. It represents one process, with distinct stages, each with an importance and meaning of its own.The meaning of the Ascension may be summarized in a phrase — mission accomplished.  Jesus accomplished what he came to do, and then he returned to the Father. The whole Gospel of John is arranged around this symmetry of Jesus coming from God and going back to God. The same pattern in implicit in the famous section in chapter 2 of St. Paul’s Letter to the Philippians about Jesus’ self-emptying (Incarnation) and eventual glorification (Ascension).The Ascension, like the Resurrection, should be viewed in a way that does not confuse time and eternity. Heaven is not a “place,” i.e. a location in time and space. Pictorial accounts of Jesus levitating while the disciples watch should be taken as a factual description of what happened. The only way we have of dealing with realities like the Ascension is through symbol and metaphor.Its occurrence forty days after the Resurrection is similarly not a reference to a specific period of time. Forty is a symbol for however long it takes for a project to be finished or completed. Thus the Israelites wandered for forty years in the desert of Sinai before they entered the promised land, that is, before they were ready or fit to enter. Moses fasted for forty days and nights on the mountain, before his vision of Yahweh and the reception of the Ten Commandments; for forty days and nights rain fell in the Deluge, until the world was cleansed; Jesus fasted in the wilderness for forty days before he was ready to being his public ministry – and he ascended from Bethany forty days after he rose. In every instance, a particular project is brought to its fitting conclusion.The Ascension signifies that Jesus is now exalted and enthroned.  Jesus ascended is Jesus in power, unrestricted as to time and place. The late Scripture scholar Raymond Brown thought that the appearances of Jesus after the Resurrection were appearances from heaven. They were evidence of his new plenipotentiary power. This is what the Ascension emphasizes. If this seems like duplication, remember that in the Gospel of John, crucifixion, resurrection, and ascension are all simultaneous. When Jesus is “lifted up” means when he rises and ascends. The entire process for St. John occurs in one eternal moment. The other gospels look at the same events from time’s earthly perspective.  Seen this way, the views are not contradictory.The new Jesus is available, as he explained to Mary Magdalene, on condition that she relinquishes her hold on the Jesus of old. She must not cling to the past, i.e. his earthly mode of existence,  if she is to receive what He can now give.This is an important spiritual principle, applicable both individually and to the Church itself. Clinging to what is past may be less a matter of protecting old forms of life than of preventing the emergence of newness. Give me the old time religion doesn’t always stem from a love of the old time religion but from apprehension regarding any new dispensation.The ascension also means the beginning of the Church. In St. Luke’s version, the disciples stand looking up to heaven, when “two men stood by them in white robes and said, ‘Men of Galilee, why are you standing there looking at the sky. This Jesus who has been taken up from you into heaven will return in the same way as you have seen him going into heaven (Acts 1:10-11).”  The disciples are, in other words, to stop stargazing and attend to their commission. Christ is in heaven; they are on earth; they are now his hands, feet, and body. They need to get on with their mission. Pentecost would provide them with empowerment from “on high” for their task.The ascended Jesus “sits at the right hand” of God the Father.  Here again we’re dealing with metaphor and symbol. On the right hand symbolizes power, position, and rank, a significance that would have been easily understood in the ancient world. It still is for us too, as when a CEO or a boss of some kind says of a colleague: “He’s my right-hand man.”Another feature of the ascension is that Jesus now reigns in his glorified human body. His humanity was not discarded after his work was done. We have no conceivable idea of what that heavenly “body” is like, though the issue speaks to our own destiny. What we must not neglect to say is that our bodies are essential to our being. We are embodied persons, not pure spirits – here and hereafter. What must be underlined is the notion of continuity, even if we cannot say what form that continuity takes.The same applies to Jesus, who is now glorified Lord of history. He reigns with the Father in his glorified body. The Incarnation was no temporary interlude in his life. It is the form God the Son assumed for ever.By: Father Henry Charles, Ph. dlast_img read more


Jose Fernandez

first_imgTragedy hit the Miami Marlins this past weekend with the death of Jose Fernandez, their 24-year old star pitcher.  His life was shortened by a boating accident in Miami.  Jose defected from Cuba in 2008 as a 15-year-old.  He was drafted by the Marlins in 2011.  In his short career he was Rookie of the Year in 2013 and he was a two-time All-Star.Our sympathies go out to the family of Jose and the Miami Marlins.  A fine young man is gone way too soon.last_img